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KMID : 0352720110350020243
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Journal of Ginseng Research
2011 Volume.35 No. 2 p.243 ~ p.249
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Protective Effect of Korean Red Ginseng against Aflatoxin B₁-Induced Hepatotoxicity in Rat
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Kim Yong-Seong
Kim Yong-Hoon
Noh Jung-Ran
Cho Eun-Sang
Park Jong-Ho
Son Hwa-Young
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Abstract
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Korean red ginseng (KRG), the steamed root of Panax ginseng Meyer, has a variety of biological properties, including anti-inflammatory, antioxidant and anticancer effects. Aflatoxin B₁ (AFB₁) produced by the Aspergillus spp. causes acute hepatotoxicity by lipid peroxidation and oxidative DNA damage, and induces liver carcinoma in humans and laboratory animals. This study was performed to examine the protective effects of KRG against hepatotoxicity induced by AFB₁ using liver-specific serum marker analysis, histopathology, and terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling. In addition, to elucidate the possible mechanism of hepatoprotective effects, superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde were analyzed. Rats were treated with 250 ㎎/㎏ of KRG (KRG group) or saline (AFB₁ group) for 4 weeks and then received 150 ㎍/㎏ of AFB1 intraperitoneally for 3 days. Rats were sacrificed at 12 h, 24 h, 48 h, 72 h, or 1 wk after AFB1 treatment. In the KRG pre-treatment group, serum alanine aminotransferase, aspartate aminotransferase, and malondialdehyde levels were low, but superoxide dismutase, catalase, and glutathione peroxidase activities were high as compared to the AFB₁ alone group. Histopathologically, AFB₁ treatment induced necrosis and apoptosis in hepatocytes, and led to inflammatory cells infiltration in the liver. KRG pre-treatment ameliorated these changes. These results indicate that KRG may have protective effects against hepatotoxicity induced by AFB₁ that involve the antioxidant properties of KRG.
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KEYWORD
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Panax ginseng, Korean red ginseng, Aflatoxin B₁, Antioxidant enzymes
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